Professor Noel Morgan
Director, Institute of Biomedical & Clinical Sciences
Endocrinology and Metabolism
Institute of Biomedical & Clinical Sciences
Skills Development Fellowship Vision
A skills development fellow would gain first-hand experience of biomedical research in an applied setting. We aim to translate findings made at the cell and molecular level to improve the understanding and treatment of type 1 diabetes. The fellow would work as part of our team and would gain experience of a wide range of relevant techniques via a hands-on approach. They would participate fully in team meetings, research presentations and journal clubs. Each project will be designed on an individual basis but would dovetail with the broader goals of the team to ensure effective enterprise, innovation and collaboration.
B.Sc.; PhD. Currently Professor of Endocrine Pharmacology in University of Exeter Medical School.
Type 1 diabetes – Immunocytochemistry; cell and molecular biology; tissue culture; islet cell enteroviral infection; pancreatic pathology.
- Morgan, N.G. 2017. Bringing the human pancreas into focus: new paradigms for the understanding of Type 1 diabetes – Dorothy Hodgkin Lecture 2017. Diabetic Med. 34, 879-886.
- Leete, P., Willcox, A., Krogvold, L., Dahl-Jorgensen, K., Foulis, A.K., Richardson, S.J. and Morgan, N.G. 2016. Differential insulitic profiles determine the extent of β-cell destruction and the age at onset of type 1 diabetes. Diabetes. 65, 1362-1369.
- Morgan, N.G. and Richardson, S.J. 2014. Enteroviruses as causative agents in type 1 diabetes: loose ends or lost cause? Trends Endocrinol. Metab. 25, 611-619.
Ongoing Projects & Grants
- 2013-2017 Diabetes UK. Subcellular disposition of fatty acids in beta cells revealed by non-linear microscopy: insights into mechanisms of beta-cell lipotoxicity. £145,000. (PI)
- 2015-2018 Diabetes UK. Investigating the relationships between fatty acid metabolism and the control of viability in human β-cells. PhD Studentship. £92,124. (Co-I).
- 2015-2016 Wellcome Trust Seedcorn Initiative: Spatiotemporal modelling of insulitis in human type 1 diabetes. £10,000. (PI)
- 2016-2018 Diabetes UK. STAT6 as a regulator of beta cell health: a previously unrecognized role in human diabetes. £158,000. (PI) 2016-2018 Diabetes UK. Depletion of the phosphatase inhibitor, PPP1R1A, may contribute to beta-cell loss in type 1 diabetes. £91,571. (PI)
- 2017-2019 MRC. Type 1 diabetes genetic risk and persistent beta cell enteroviral infection – a lethal combination? £392,000. (Co-I).
- 2017-2019 Diabetes UK. Characterisation of immune cell interactions in the insulitic infiltrate of patients with recent-onset Type 1 diabetes. £164,000. (PI)
- 2017-2019 JDRF. The JDRF nPOD-Virus Group: Towards Vaccine Development. $144,000. (Co-I).
- 2017-2020 Norman Family Trust. Enteroviral infection in human beta cells: a possible causative factor in type 1 diabetes. £90,000. (Co-I).
We collaborate extensively with multiple colleagues across Europe and the USA and hold joint grant awards as part of European and US-based consortia.
Research Group Connections