Professor Christian Soeller
Professor of Physical Cell Biology
Living Systems Institute
Skills Development Fellowship Vision
I see my role as providing a Skills Development Fellow (SDF) with guidance on how to appreciate the underlying biology/biomedical problem and link this effectively with the application of quantitative skills. A successful SDF will use the new skills (in either biology or quantitative areas) while understanding the constraints of the biological or biomedical systems he/she is dealing with and use their skills to look at the associated problems in new and possibly unusual ways enabled by their fresh perspective. There are inherent challenges in interdisciplinary work and as somebody with extensive experience in interdisciplinary research, having previously worked both in Medical Schools and Physics Departments, I will assist the fellow in mastering the language of the areas new to them and use their existing skills effectively. Assuming that quantitative imaging will be useful for their project, I will share my expertise and advise the fellow how such methods could be employed.
I would expect the fellow to work quite independently but develop a network of colleagues they can frequently consult for questions surrounding their interdisciplinary project (which will have many aspects new to the fellow). A sponsor will help them stay on track by providing frequent feedback and being a discussion partner to bounce ideas off.
Collaborative networks will include experimentalists who work on the system they model/work on, as well as colleagues and peers who conduct similar interdisciplinary work. The fellow may work with additional national and international experts, possibly beyond Exeter, as required by specific questions in their project(s). The latter will also help the fellow build a robust network in their new field.
- PhD in Physics, University of Goettingen
- Associate Professor, Biophysics, Department of Physiology, University of Auckland
Calcium dynamics; nanoscale biology of signalling; advanced fluorescence imaging, super-resolution imaging; mathematical modelling of calcium dynamics; image data analysis; non-linear least squares and maximum-likelihood methods for single molecule localisation
- J Charles G Jeynes, Kalotina Geraki, Christopher Jeynes, Mi Zhaohong, Andrew A Bettiol, Eva Latorre, Lorna Wendy Harries, and Christian Soeller. Nanoscale Properties of Human Telomeres Measured with a Dual Purpose X-Ray Fluorescence and Super Resolution Microscopy Gold Nanoparticle Probe. ACS nano, 2017 p. acsnano.7b07064.
- Vijay Rajagopal, Gregory Bass, Cameron G Walker, David J Crossman, Amorita Petzer, Anthony Hickey, Ivo Siekmann, Masahiko Hoshijima, Mark H Ellisman, Edmund J Crampin, and Christian Soeller. Examination of the Effects of Heterogeneous Organization of RyR Clusters, Myofibrils and Mitochondria on Ca2+ Release Patterns in Cardiomyocytes. PLoS Comput Biol, 2015 vol. 11 (9) p. e1004417.
- 2009. Baddeley D, Jayasinghe ID, Lam L, Rossberger S, Cannell MB, Soeller C. Optical single-channel resolution imaging of the ryanodine receptor distribution in rat cardiac myocytes, Proc Natl Acad Sci U S A, volume 106, no. 52, pages 22275-22280, DOI:10.1073/pnas.0908971106
Ongoing Projects & Grants
- EPSRC grant on new super-resolution imaging method for pathology applications
- BBSRC grant on super-resolution imaging of plant signalling
- BBSRC grant on imaging tools development using DNA nanotechnology
- HFSP Investigation of nanoscale signalling structures in the heart
- Bioengineering, University of Melbourne (cardiac calcium modelling)
- Bioscience, University of Queensland (skeletal muscle Ca2+ signalling)
- Physiology, University of Auckland, (Nanoscale Fluorescence Imaging)
- Baylor College of Medicine, Texas, (ryanodine receptor and accessory protein physiology)
Research Group Connections