Dr Jon Brown
Neuroscience and Neurology
Institute of Biomedical and Clinical Sciences, University of Exeter Medical School
Skills Development Fellowship Vision
The fellow should develop NEW skills in a completely new (but relevant and strategically important) field of study. For example, a fellow who has excellent biomedical research skills (in for example, in vivo electrophysiology) should develop an entirely new set of skills which complement the research area. I would expect that they should be able to work fairly autonomously in the area they are already an expert in, but would require initial assistance and training in the area of skills development. However, by the end of the fellowship I would hope that the fellow would be fully trained in the new area and able to apply her/his new skills in combination with their existing expertise to an important area of biomedical research.
Thus the fellow will be in a position to obtain substantial interdisciplinary funding. I would expect a fellow to develop collaborations within both the existing and new areas of expertise. For the new skills area, I would expect, initially, most of these collaborations to be local (i.e. within the University), although as the fellow develops these skills s/he may begin to build a more extensive collaborative network. On the other hand for the development of existing skills, I would expect the fellow to be starting to build international collaborative networks.
- Senior Research Fellow (Jan 2013 – Apr 2016) Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, University of Exeter.
- Research Fellow (May 2010 – Jan 2013), Research Associate (Jul 2006 – May 2010) School of Physiology and Pharmacology, University of Bristol.
- Principal Scientist (Apr 2006 – Jul 2006), Senior Scientist (Oct 2004 – April 2006), Scientist (Oct 2002 – Oct 2004), Associate Scientist (Sep 2001 – Oct 2002), Neurology & GI Centre of Excellence for Drug Discovery, GlaxoSmithKline, Harlow, UK.
- Doctor of Philosophy (PhD) 2000-2004 Master of Research (MRes) 1999-2000 Bachelor of Science (Hons) 1996-1999
Dementia research. Specifically interested in neuronal network dysfunction associated with cognitive dysfunction. We use electrophysiological techniques, both in brain slices and increasingly in vivo to explore these questions.
- Booth C, Witton J, Nowacki J, Tsaneva-Atanasova K, Jones MW, Randall AD, Brown JT (2016) Altered Intrinsic Pyramidal Neuron Properties and Pathway-Specific Synaptic Dysfunction Underlie Aberrant Hippocampal Network Function in a Mouse Model of Tauopathy. J Neurosci. 36:350-63
- Booth C, Ridler T, de Groot E, Phillips KG, Randall AD, Brown JT (2016) Electrical and network neuronal properties are preferentially disrupted in dorsal, but not ventral, medial entorhinal cortex in a mouse model of tauopathy. J Neurosci. 36:312-24
- Witton J, Staniaszek, LE, Bartsch U, Randall AD, Jones MW, Brown JT (2016) Disrupted hippocampal sharp-wave ripple-associated spike dynamics in a transgenic mouse model of dementia. J Physiol. 594(16):4615-30
Ongoing Projects & Grants
- 2017 Alzheimer Research UK. Title: Functional consequences of impaired gamma frequency oscillations in mouse models of dementia.
- 2017 Alzheimer Research UK. Title: Improving Neurotransmission through the Brain’s Memory Centres: A Pharmacogenetic Approach to Treating Dementia.
- 2017 Janssen PhD studentship
- 2016 Alzheimer Research UK. Title: Contribution to the purchase of a Ti-Sapphire laser to enable establishment of multiphoton fluorescence imaging facility. Role: Co-Investigator (PI: Prof Andy Randall)
- 2016 Wellcome Trust. Title: A multiphoton imaging facility for in vitro and in vivo studies of CNS function and disease. Role: Co-investigator (PI: Prof Andy Randall)
- 2016 Medical Research Council studentship. Title: Relationship between synaptic dysfunction and degeneration in a rodent model of dementia
Current collaborations with teams in Bristol and Edinburgh. Beyond academia I have close ties with the pharmaceutical industry and have currently funded collaborations with Janssen and Eli Lilly
Research Group Connections