Dr Mick Craig
Senior Research Fellow
Neuroscience and Neurology
Skills Development Fellowship Vision
A successful fellowship would combine quantitative techniques with real, hands-on experimental work. While the candidate would require training in the appropriate experimental/quantitative methods in the initial months, I would both encourage and expect them to develop their independence quickly, through setting their own research goals and research direction, with input from more senior colleagues. A fellowship is often a stepping-stone to securing an independent position, so the ideal candidate would be someone who can bring their own ideas that they can develop and build upon for the next stage of their career.
- DPhil Neuroscience University of Oxford (2011)
- MSci (hons) Neuroscience, University of Glasgow (2006)
- 2011-2016: Postdoc, NIH, USA (McBain lab)
- 2011: Postdoc, University of Cambridge (Pauslen lab)
Main interests: long-range communication between different parts of the brain, relating knowledge of cellular circuitry to physiology and behaviour. I have particular interests in inhibitory interneurons and neuronal oscillations.
Techniques: electrophysiology (in vivo and in vitro), recovery surgery, optogenetics / pharmacogenetics, anatomy, virus-assisted circuit mapping, histology and behaviour.
- Craig MT & McBain CJ (2015). Fast gamma oscillations are generated intrinsically in CA1 without the involvement of fast-spiking basket cells. J Neurosci 35(8): 3616-24
- Chittajallu R*, Craig MT*, McFarland A*, Yuan X, Gerfen S, Tricoire L, Erkkila B, Barron SC, Lopez CM, Liang BJ, Jeffries BW, Pelkey KA, McBain CJ (2013). Dual origins of functionally distinct O-LM interneurons revealed by differential 5-HT3AR expression. Nature Neurosci 16(11): 1598-607
- Xiao MF*, Xu D*, Craig MT, Pelkey KA, Chien CC, Shi Y, Zhang J, Resnick S, Pletnikova O, Salmon D, Brewer J, Edland S, Wegiel J, Tycko B, Savonenko A, Reeves RH, Troncoso JC, McBain CJ, Galasko D, Worley PF (2017). NPTX2 and Cognitive Dysfunction in Alzheimer’s Disease. eLife 2017;6:e23798
Ongoing Projects & Grants
- 2017 Alzheimer’s Research UK. Role: PI. Amount: £249,669. Interdisciplinary Research Grant. Title: Improving Neurotransmission through the Brain’s Memory Centres: A Pharmacogenetic Approach to Treating Dementia.
- 2017 Alzheimer’s Research UK. Role: co-investigator (PI: Dr Jonathan Brown). Amount: £278,500. Project Grant. Title: Functional consequences of impairments to gamma frequency network oscillations in mouse models of dementia.
- 2017 MRC. Role: PI / Lead supervisor. Amount: ~£90,000. PhD studentship awarded from MRC GW4 DTP programme. Title: Circuit mechanisms of disrupted neuronal network function in Alzheimer’s disease.
- 2016 BBSRC. Role: PI. Amount: £322,999. New Investigator Award. Title: Investigating the role of the thalamic nucleus reuniens in relaying prefrontal cortex input to the hippocampus.
- 2016 Wellcome Trust. Role: co-investigator (PI: Prof Andrew Randall). Amount: £584,000. Multi-user Equipment Grant. Title: A multiphoton imaging facility for in vitro and in vivo studies of CNS function and disease.
I have ongoing collaborations with:
- Dr Chris J McBain, National Institutes of Health, USA; hippocampal interneurons and development
- Prof Bernhard Bettler, University of Basel, Switzerland; GABAB receptors & auxiliary subunits
- Prof Paul Worley, Johns Hopkins University, USA; neuronal pentraxins
- Prof Dieter Saur, Technical University of Munch, Germany; monosynaptic rabies tracing
- Prof Joseph Gogos, Columbia University, USA; 22q11.2 deletion syndrome
- Prof Andy Randall, University of Exeter; Alzheimer’s disease and thalamocortical circuits
- Prof Vincenzo Crunelli, University of Cardiff; Alzheimer’s disease and thalamocortical circuits
- Dr Jon Brown, University of Exeter; Alzheimer’s disease and network function
- Prof John Aggleton, University of Cardiff, Circuitry of retrosplenial cortex and subiculum
- Dr Michael Kohl, University of Oxford, In vivo calcium imaging and behaviour
Research Group Connections